``on´´ neurons directly or indirectly from brain structures related with the organization of
Tài liệu Báo cáo khoa học: Antimicrobial effects of H4-(86–100), histogranin and related compounds – possible involvement of DNA gyrase ppt
Ngày tải lên :
18/02/2014, 14:20
... than the parent peptides, stressing the importance of the integrity of the molecule (15 amino acids) for bactericidal activity However, the addition of Gly-Gly in the C-terminal portions of H4-(86–100) ... H4-(86–100) form a-helical structures pertains to their ability to associate with plasma membranes and other hydrophobic cellular organelles The theoretical helical wheel conformation of HNr shows the ... of the DNA gyrase inhibitory activity of HN with those of ciprofloxacin, LL-37 and ampicillin (an antibiotic acting as an inhibitor of cell wall synthesis) indicated that the inhibitory effect of...
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Báo cáo khoa học: Possible involvement of an FKBP family member protein from a psychrotrophic bacterium Shewanella sp. SIB1 in cold-adaptation potx
Ngày tải lên :
16/03/2014, 16:20
... produce the 450 bp NdeI-EcoRI fragment containing the 5¢-terminal region of the Ec-fklB gene, or by EcoRI and SalI to produce the 250 bp EcoRI-SalI fragment containing the 3¢-terminal region of the ... and at least one of other proteins, are shaded Numbers above the sequences indicate the positions of the residues relative to the initiator methionine of SIB1 FKBP22 The ranges of the a-helices ... 3) Furthermore, at the core of the dimerization domain, two methionine residues (Met38 and Met42) located in the a2 helix of one monomer make hydrophobic interactions with those of the other monomer...
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Báo cáo y học: "Expression and function of inducible co-stimulator in patients with systemic lupus erythematosus: possible involvement in excessive interferon-γ and anti-double-stranded DNA antibody production" pot
Ngày tải lên :
09/08/2014, 07:20
... soluble factors secreted into the medium The cells were cultured for seven days and the supernatants were collected With or without stimulation, the separation of B cells from T cells using the filter ... about 29 kDa was immunoprecipitated with JTA009 but not with JMAb23, the control antibody The thin lower band corresponded to the position of the front dye of the gel Human ICOS expressing (c) ... on either CD4+CD45RO+ or CD8+CD45RO+ T cells and analyzed the expression of ICOS on these subsets (Figure 2a–f) We determined the cutoff points for positive staining so that the percentage of positive...
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Báo cáo y học: " Involvement of the genicular branches in cystic adventitial disease of the popliteal artery as a possible marker of unfavourable early clinical outcome: a case report" pps
Ngày tải lên :
11/08/2014, 12:20
... with the report of Crolla et al [8] that focuses mainly on the diagnostic use of MRI in CAD, are the only reports describing the involvement of the adventitia of the genicular arteries The early ... arteries could be a predictor of higher risk of recurrence, either as an indicator of cysts communicating with the knee synovium or as a marker of the involvement of smaller vessels elsewhere ... recurrence of symptoms in our patient, in the absence of any radiologically apparent luminal stenosis of the popliteal artery, raises the question of the potential significance of the involvement of...
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ISOTOPE HYDROGRAPH SEPARATION FOR MODELING OF RUNOFF MECHANISMS OF ATMOSPHERICALLY DERIVED CHEMICAL AND RADIOACTIVE POLLUTANTS
Ngày tải lên :
05/09/2013, 09:08
... to the amount-weighed mean δD of the precipitation samples (-28.1 ‰), and C2 was set to the δD of the river water just before the precipitation event (-47.9 ‰) For the main part of the runoff ... in the central part of the watershed and are discussed hereafter This is because records of the δD of precipitations at another location in the same part differed only by 0.5 ‰ from the former ... analyzed or reported previously As a result of the calculation, and by setting C1 and C2 as mentioned above, the fraction of new water evaluated for the main part of the runoff (0000 of Oct 22...
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Tài liệu Báo cáo khoa học: Synchronization of Ca2+ oscillations: involvement of ATP release in astrocytes pdf
Ngày tải lên :
16/02/2014, 09:20
... nearly correlated with the strength of the sensory stimulation Thus, neuronal activities also affect astrocytic Ca2+ transients More importantly, the application of bicuculine, an antagonist of 4-aminobutyrate ... and activation of which results in the formation of Ins(1,4,5)P3, leading to Ca2+ release from Ca2+ stores (B) Multiple pathways for the release of ATP Hemichannels of connexin or pannexin, maxi-anion ... the velocity of ATP release correlates well with that of the Ca2+ wave in astrocytes [5] All of these findings suggest that the extracellular molecule ATP could be a primary signal for the Ca2+ wave...
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Tài liệu Possible influences of air pollution, dust- and sandstorms on the Indian monsoon doc
Ngày tải lên :
17/02/2014, 22:20
... may be largely a reflection of the seasonal variations of the meteorological conditions 40N The bulk properties of the aerosols can be inferred from the variations of the Ångstrøm exponent (Figure 3(b)) ... September-October-November able for the period 1979 to 2005, with a data gap, from 1993-1996 The increase in atmospheric loading of absorbing aerosols, preceding the northward movement of the monsoon rainband, ... concentration of coal-firing industrial plants Most of the aerosols are the absorbing species—black carbon from coal and biofuel burning, biomass burning and dust During the northern spring and...
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Tài liệu Báo cáo khoa học: Hypoxic resistance to articular chondrocyte apoptosis – a possible mechanism of maintaining homeostasis of normal articular cartilage pdf
Ngày tải lên :
18/02/2014, 14:20
... death via the caspase pathway, the key regulator of the TRAIL-induced cell death pathway in canine chondrocytes Furthermore, cotreatment of cells with both ALLN and TRAIL increased JNK phosphorylation ... examinations were also performed The severity of osteophyte formation in the femoropatellar, lateral femorotibial, medial femorotibial and central femorotibial joints was graded from to 3: grade 0, ... (Fig 3A) The examination of cell morphology also supported the enhancing effect of combined ALLN and TRAIL treatment in canine chondrocytes (Fig 3B) To determine whether treatment with the proteasome...
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Tài liệu Báo cáo khoa học: Dual P2Y12 receptor signaling in thrombin-stimulated platelets – involvement of phosphoinositide 3-kinase b but not c isoform in Ca2+ mobilization and procoagulant activity pdf
Ngày tải lên :
18/02/2014, 16:20
... present, the PKA inhibitor H89 further reduced the rate of thrombin generation by another 25%, thus indicating the additional involvement of PKA To assess more directly the role of the P2Y12 ... is in accordance with the known affinity of these compounds for the PI3-K catalytic subunits At these concentrations (required for notable inhibition of Akt phosphorylation; see below), wortmannin ... increase of the first Ca2+ peak and a more marked increase of the later Ca2+ signal Furthermore, the strong inhibitory effect of post-added AR-C indicates FEBS Journal 275 (2008) 371–385 ª 2007 The...
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Tài liệu Báo cáo khoa học: Characterization of human deoxyribonuclease I gene (DNASE1) promoters reveals the utilization of two transcription-starting exons and the involvement of Sp1 in its transcriptional regulation ppt
Ngày tải lên :
19/02/2014, 06:20
... over the diagrams indicate the position of the corresponding nucleotides relative to the translation start site, and the numbers in parentheses below the diagram show the position of the corresponding ... that of pGL3–basic vector and was half that of pGL3–promoter vector These findings demonstrate the promoter activity of the 5¢-flanking region of exon in DNASE1 Deletion of the upstream end of the ... ligating the fragment into the EcoRI ⁄ XhoI site of pcDNA3.1(+) vector (Invitrogen Corp.) The nucleotides underlined in the primer sequences above represent EcoRI or XhoI sites The 5¢-UTRs of the...
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Tài liệu Báo cáo khoa học: Unfolding of human proinsulin Intermediates and possible role of its C-peptide in folding/unfolding pptx
Ngày tải lên :
19/02/2014, 12:20
... disulfide formation pathway of PIP in vitro Intermediates are named using the disulfide bonds they contain Arrows with dashed lines indicate the folding pathway for the first formation of the intra-A ... that a correlation exists in the molecular mechanism of the unfolding or refolding of HPI Discussion Although the insulin A- and B-chains contain sufficient structural information for the correct ... conclude that the main function of the C-peptide in the folding process is to provide the necessary flexibility for the formation of intramolecular disulfide bonds However, the manner in which the C-peptide...
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Tài liệu Báo cáo khoa học: Regulation of connective tissue growth factor (CTGF/CCN2) gene transcription and mRNA stability in smooth muscle cells Involvement of RhoA GTPase and p38 MAP kinase and sensitivity to actin dynamics docx
Ngày tải lên :
19/02/2014, 16:20
... Conversely, the active form CA-Rac1 failed to affect the expression of CTGF/CCN2, thus corroborating the previous data obtained with the dominant negative form of Rac1 The relatively potent activation of ... evidence support an obligatory role for the actin cytoskeleton in the regulation of specific genes by small GTPase proteins The morphology of the actin cytoskeleton upon treatment of the cells with S1P, ... stimulate the expression of CTGF/CCN2 efficiently [8,43–45] The role of the cytoskeleton is important, particularly in the compartmentalization of the cytoplasm and organization of specialized zones for...
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Tài liệu Báo cáo khoa học: Involvement of two positively charged residues of Chlamydomonas reinhardtii glyceraldehyde-3-phosphate dehydrogenase in the assembly process of a bi-enzyme complex involved in CO2 assimilation doc
Ngày tải lên :
19/02/2014, 16:20
... position of NADH and of NADPH, these substrates were initially docked in the same position as the NAD of GD1 Parameters for both cofactors were taken from the AMBER web site The 10 structures ... suggesting that the active site and the cofactor-binding site of the mutant R197A are not modied by the mutation We thus assume that the conformation of the R197A mutant is close to that of the wild-type ... dichroism, uorescence spectra and molecular modelling of all mutant GAPDHs indicate no changes of the global structure of the mutants To test whether the interactions of these mutants with the other...
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Tài liệu Báo cáo khoa học: A possible role of mitochondria in the apoptotic-like programmed nuclear death of Tetrahymena thermophila Takashi Kobayashi and Hiroshi Endoh docx
Ngày tải lên :
20/02/2014, 03:20
... report and our observations of the monomeric form of DePsipher in the autophagosome together, the mitochondria taken in the autophagosome might be broken, once they were incorporated into the ... (merged colour of green and orange), resulting from the fusion of the nuclei and lysosomes, as reported previously [22] Green fluorescence of DePsipher did not directly show the localization of mitochondria ... stained green with AO (Fig 2) The localization of the acidic organelles (Fig 2) is clearly different in distribution and in number from that of the green fluorescent signals of the FEBS Journal...
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Tài liệu Báo cáo khoa học: Characterization of the promoter for the mouse a3 integrin gene Involvement of the Ets-family of transcription factors in the promoter activity doc
Ngày tải lên :
21/02/2014, 03:20
... inserted into the KpnI/SacI site of Fig Structures of the 5¢-flanking region of mouse a3 integrin gene The map (upper line) shows the organization of exons 1–3 and the 5¢-flanking region with the positions ... factor of the Ets-family is involved in the regulation The members of the Ets-family of transcription factors bind to specific purine-rich sequences with a core motif of GGAA/T and control the ... IV [57] The former enzyme is responsible for the synthesis of the b1–6 branch in N-acetyllactosamine units in cell surface N-glycans, and the latter enzyme is involved in the synthesis of cell...
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Tài liệu Báo cáo Y học: Tissue factor pathway inhibitor A possible mechanism of action doc
Ngày tải lên :
22/02/2014, 04:20
... applicability of the latter In addition, Scheme allows consideration of the factor Xa influence on the system behavior The differential equations for the concentrations of the reactants based on the law of ... constants are unknown The discussion of the criteria for choosing of the values of these constants is presented below The factor X activation was assumed to involve the formation of the enzyme–substrate ... predicts too weak inhibition of the factor Xa activation and cannot describe the experiments of the study To test the adequacy of our model and the correctness of the values of the unknown constants...
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Báo cáo khoa học: Involvement of lysine 1047 in type I collagen-mediated activation of polymorphonuclear neutrophils doc
Ngày tải lên :
07/03/2014, 06:20
... in the carbamylation rate of collagen CNBr peptides obtained from the incubation of collagen with cyanate and to establish a correlation between the number of spots detected and the number of ... when the residue is modified Two hypotheses may explain the role of lysine 1047: either this amino acid participates in the stabilization of the DGGRYY sequence conformation or it interacts directly ... responsible for a decrease in the isoelectric point (pI) (Fig 4) As the shift of spots towards a lower pI was directly related to the carbamylation rate of peptides, each new spot corresponded to the...
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Báo cáo khoa học: 7-Ketocholesterol-induced apoptosis Involvement of several pro-apoptotic but also anti-apoptotic calcium-dependent transduction pathways ppt
Ngày tải lên :
07/03/2014, 21:20
... p90RSK We therefore tested the hypothesis that ERK could reduce apoptosis by phosphorylating BAD To characterize the importance of the ERK pathway in the activation ⁄ inhibition of BAD during the early ... of these kinases We next examined the ability of the MAPK signalling pathway to inhibit, via p90RSK, the apoptotic effect of 7-ketocholesterol by phosphorylating BAD Treatment of cells with the ... inactivating the pro-apoptotic protein BAD Our previous results also suggest the possibility of the involvement of other Ca2+-initiated cell death pathways Therefore our results showing the release of the...
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